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The current study investigated sub-regional variants in corpus callosum integrity in ALS, and whether these reflect a relationship utilizing the growth of unilateral or bilateral limb weakness. Methods Sporadic ALS patients were classified into unilateral (letter = 14) or bilateral (letter = 25) limb weakness during the time of assessment and underwent diffusion tensor imaging. Probabilistic bundle-specific monitoring had been completed using MRtrix and TractSeg to parcellate the