https://www.selleckchem.com/pr....oducts/d-lin-mc3-dma
Periodontitis is an inflammatory bone loss disease initiated by oral bacterial inflammation. Herein, we determined whether inhibition of sphingosine-1-phosphate receptor 2 (S1PR2, a G protein-coupled receptor) by its specific antagonist, JTE013, could alleviate ligature-induced periodontitis in mice. C57BL/6 mice were placed with silk ligatures at the left maxillary second molar to induce experimental periodontitis. Mice were treated with JTE013 or control vehicle (dimethyl sulfoxide, DMSO) oral topically on the ligatures once dai