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7%, P 0.05 vs placebo). Nocturnal HR mean values were significantly increased by lorazepam (+10.1%, P 0.01 vs placebo), whereas they did not change after alprazolam. In patients with mild hypertension, oral intake of alprazolam or lorazepam as hypnotics did not affect ambulatory BP or HR values. A slight increase in nighttime DBP was observed with lorazepam, whereas alprazolam showed no effect on nocturnal BP and HR, probably reflecting a stimulating effect of the drug on central α2-receptors. In patients with mild hypertensi