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After irradiation, we show that Lgr5+ISC restoration DNA damage more efficiently than their particular progenitors and therefore this security is Atg7 dependent. Appropriately, we discovered that the stimulation of autophagy on fasting protects Lgr5+ISC against DNA harm and cell death mediated by oxaliplatin and doxorubicin treatments. Eventually, p53 deletion stops the death of Atg7-deficient Lgr5+ISC but encourages genetic uncertainty and tumor development. Entirely, our findin
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