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CONCLUSION Our information broadened the hereditary and phenotypic variations of congenital aniridia, and showed the therapeutic aftereffect of nonsense suppression with this disease utilizing patient-derived cells. © 2020 The Authors. Molecular Genetics Genomic Medicine published by Wiley Periodicals, Inc.The inadequacy of conventional cell-monolayer planar cultures and animal experiments in predicting the toxicity and medical effectiveness of medicine prospects has actually led to an imminent de