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ection among MSSA-PENS-blaZnegative isolates of the clonal lineage CC398 or the absence of an IEC raises questions about their possible animal origin, requiring further analysis. Studies of adults with Crohn's disease (CD) suggest that poor mental health precedes worsening disease activity. We evaluated whether depression and/or anxiety forecast worsening pediatric CD disease activity. Through the Inflammatory Bowel Disease Partners Kids Teens internet-based cohort, children with CD age 9 to 17 completed Patient-Reported Outcomes M