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3 vs 18.5 ml, p = 0.003), core volume (27.8 vs 1.0 ml, p 0.001), and unfavorable mismatch (0.51 vs 0.91, p 0.001) were found during the COVID-19 period compared to no-COVID-19 one. The more unfavorable perfusion pattern at admission resulted in higher infarct volume on follow-up CT during COVID-19 (35.5 vs 3.0 ml, p 0.001). During lockdown, a reduction of stroke admissions (- 37%) and a higher prevalence of severe clinical presentation (NIHSS ≥ 10; 53% vs 36%, p = 0.029) were observed. The results of CTP analysis provided