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PRAME-stimulated cultures ( =1 had mean expansion of 2500-fold at day 18. Mean CD3 percentage was 96% with CD4CD8 ratio of 41. Re-exposure to PRAME peptide mixture showed enrichment of CD4 cells expressing interferon (IFN)-γ (mean 12.2%) and TNF-α (mean 19.7%). Central and effector memory cells were 23% and 72%, respectively, with 24% T cells expressing PD1. Mass cytometry showed predominance of Th1 phenotype (CXCR3 /CCR4 /CCR6 /Tbet , mean 73%) and cytokine production including IL-2, IL-4, IL-8, IL-13 and GM-CSF (2%, 6%, 8%, 4% and 1