https://www.selleckchem.com/pr....oducts/epacadostat-i
Biomolecular condensates are formed by liquid-liquid phase separation (LLPS) of multivalent molecules. LLPS from a single ("homotypic" constituent is governed by buffering above a threshold, free monomer concentration is clamped, with all added molecules entering the condensed phase. However, both experiment and theory demonstrate that buffering fails for the concentration dependence of multicomponent ("heterotypic" LLPS. Using network-free stochastic modeling, we demonstrate that LLPS can be described by the solubility
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