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05) compared to control. CsA increased blood pressure (by 46mmHg) and decreased creatinine clearance (by 49%, all P less then 0.05). Treatment of CsA rats with apocynin, catalase, and their combination decreased blood pressure to near control values (all P less then 0.05). NOX4 mRNA activity was higher in the renal tissue of CsA rats by approximately 63% (P less then 0.05) compared to controls but was reduced in apocynin (by 64%), catalase (by 33%) and combined treatment with apocynin and catalase (by 84%) compared to untreated CsA rat
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