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The proinflammatory cytokine IL-1 significantly augmented P2R-induced IL-6 production by HSC-2cells via the nuclear factor-κB signaling pathway. The present study suggests that P2Rs signaling and IL-1 synergistically induce chronic inflammation in OSCC. Because chronic inflammation is a well-known driving force of tumor progression, these results support therapeutic strategies that target P2Rs signaling in OSCC. The present study suggests that P2Rs signaling and IL-1 synergistically induce chronic inflammation in OSCC. Because chronic in