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9-6.4, p .001), and PVD (HR 3.5, 95% CI 1.6-7.5, p = .001). When 2 risk factors were present, 99.1% and 96.8% retained their hindfoot at 5 and 10 years, respectively. However, this decreased to 87.3% and 80.1% with two risk factors and fell to 63.3% and 43.3% with three risk factors. Failure of limb salvage was increasingly likely as the number of identified independent risk factors increased. These results may assist in prognostication and shared decision making between patients and providers. Prognostic, Level III. Prognostic,
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