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The predictive model algorithm had a c-statistic of 0.95. The model's probability threshold of 0.60 excluded 89% (84/94) of false positives identified by the screening algorithm, with a PPV of 94% (95% CI 91%-98%). The model excluded very few true positives (15 of 178), and identified 92% (95% CI 87%-96%) of the cases selected by the screening algorithm. Predictive modeling techniques yielded an accurate algorithm with high PPV and sensitivity for identifying anaphylaxis in administrative claims. This algorithm could be considered in f