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None of the models presented acceptable values of bias and inaccuracy. Conclusion While performing external evaluations on some populations may confirm a model's suitability to diverse groups of patients, there is still some variability that cannot be explained nor solved by the procedure. This brings to light the difficulty to develop only one model for ICU patients and the need to develop one specific model to each population of critically ill patients.Purpose Laboratory reference intervals (RIs) play a key role in clinical pharmaco

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