https://rafsignal.com/index.ph....p/adrenergic-crisis-
Right here we solve the structure of HglS to 1.1 Å resolution in substrate-free kind plus in complex with 2OA. We propose a successive decarboxylation and intramolecular hydroxylation apparatus developing 2HG in a Fe(II)- and O2-dependent way. Specificity is mediated by a single arginine, very conserved across many DUF1338 proteins. An Arabidopsis thaliana HglS homolog coexpresses with understood lysine catabolism enzymes, and mutants reveal phenotypes in line with disrupted lysine cata
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