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Thus, using SUs in place of SGLT2-i and GLP-1RAs may deprive patients of key advantages and potentially important cardiorenal benefits. In subjects with ascertained cardiovascular disease or at very high cardiovascular risk, SGLT2-i and/or GLP-1RAs should be used as part of diabetes management, in the absence of contraindications. Routine utilization of SUs as second line agents continues to be acceptable in resource-constrained settings. This article is protected by copyright. All rights reserved.With the introduction of clotting factor conc