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Erich Letterer (1895-1982) is without any doubt one of the most renowned German pathologists of the 20th century. As the eponym of the "Letterer-Siwe disease" and as a pioneer in the field of immunopathology, he made his mark in medical history. Less well known is the fact that Letterer achieved the decisive career step - the call to a full professorship - in the Third Reich, at the explicit request of authoritative National Socialists. In post-war Germany, on the other hand, Letterer was considered a politically unencumbered, honorable