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Obesity is associated with a unique non-T2 asthma phenotype, characterised by a Th17 immune response. Retinoid-related orphan receptor C (RORC) is the master transcription factor for Th17 polarisation. We investigated the association of TNFA, IL17A, and RORC mRNA expression levels with the non-T2 phenotype. We conducted a cross-sectional study in adolescents, subdivided as follows healthy (HA), allergic asthma without obesity (AA), obesity without asthma (O, and non-allergic asthma with obesity (NAO). TNFA, IL17A, and RORC mRNA expressio
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