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Treatment with FOLFOX resulted in a significant increase of h-FABP levels, increased myocardial fibrosis, and apoptosis as well as increased expression of type I Collagen. Furthermore, FOLFOX caused a decrease of LVEF by 10% ( = 0.028). Dietary glycine prevented FOLFOX-induced myocardial injury by preserving the LVEF and reducing the levels of fibrosis ( = 0.012) and apoptosis ( = 0.015) in vivo. Data presented here demonstrate for the first time that dietary glycine protects the heart against FOLFOX-induced injury during treatment for