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Results In total, 25 articles involving 1920 subjects with 3493 experimental results had been included. A lot of the scientific studies had been of reasonable high quality. A higher level of heterogeneity (I2=57.2%, p less then 0.001) ended up being discovered. The Youden index values had been 1.56 and 1.55 whenever CPOT threshold was set at two and three, correspondingly. The diagnostic overall performance for the CPOT was suffering from the guide standard. The CPOT had an increased diagnost

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