https://www.selleckchem.com/pr....oducts/ex229-compoun
Taken together, our results demonstrate the functional importance of residues located outside the antigen-binding site in affinity maturation.Background Neutralizing anti-drug antibodies (ADA) can greatly reduce the efficacy of biopharmaceuticals used to treat patients with multiple sclerosis (MS). However, the biological factors pre-disposing an individual to develop ADA are poorly characterized. Thus, there is an unmet clinical need for biomarkers to predict the development of immunogenicity, and subsequent treatment failur
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