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001). The scores in Jiuzhi Group were significantly lower compared with the Lhasa Group (p  less then  0.001). The changes in oxy-Hb in channels 6 and 15 in both high-altitude groups were significantly greater compared with the Beijing Group (p  less then  0.05), without significant difference between the two high-altitude groups. GDP was significantly correlated with all the scores (p  less then  0.001), but not altitude. Conclusions Cognitive impairment occurs in adolescents at high altitude, being severer in Jiuzhi Group compared with