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RO122 removal rate increased as initial oxidant concentration and temperature increased and reduced as initial RO122 concentration increased. Energy requirements and oxidant costs were assessed. The UV/H2O2 process was concluded to be the most efficient and economic process for RO122 removal. Graph theoretical network analysis with structural magnetic resonance imaging (MRI) of multiple sclerosis (MS) patients can be used to assess subtle changes in brain networks. However, the presence of multiple focal brain lesions might impair the ac