https://www.selleckchem.com/pr....oducts/4-hydroxynone
The hippocampus is affected by tau pathology early in Alzheimer's disease (AD) development. Accurate quantification of hippocampal tau signal using the tau-PET tracer F-flortaucipir is complicated, however, by off-target binding in the adjacent choroid plexus. We here present a new method for compensating for this off-target choroid plexus signal. As off-target binding in the choroid plexus is known to be higher using F-flortaucipir compared to F-RO948, we created a binary hippocampal mask in template space where F-flortaucipir