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001) were observed in the Dox control group. All these parameters were reversed significantly (p less then 0.05) in the plant-pretreated group. The histopathological assessment of myocardial damage provided supportive evidence for the biochemical results obtained. Inflammatory markers, myeloperoxidase, expression of TNFα and caspase-3, and DNA fragmentation (TUNEL positive nuclei) were significantly elevated (p less then 0.05), and expression of Bcl-2 was significantly decreased (p less then 0.05) in the Dox control; however, all these

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