https://www.selleckchem.com/pr....oducts/cyclo-rgdyk.h
Molecular dynamics simulations along with dynamic light scattering experiments suggest that mPPCs form globular structures in solution due to ligand-ligand interactions. Such interactions are key to the spatial proximity of ligands and thus to the multivalency effect of mPPC inhibition. Excess ligand-ligand interactions, however, reduce the accessibility of mPPC ligands to Aβ peptides, and impair the overall inhibition potency.Background Botulinum neurotoxin therapy (BoNT) is a powerful tool for treating many neurologic disorders. T