https://www.selleckchem.com/pr....oducts/pyridostatin-
Tofacitinib is an oral, small-molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). We summarize the efficacy and safety data of tofacitinib 5 or 10 mg twice daily in the UC clinical program, stratified by prior tumor necrosis factor inhibitor (TNFi) failure status. Efficacy was assessed in the pooled phase 3 OCTAVE Induction 1 and 2 studies (N= 1139), the phase 3 OCTAVE Sustain maintenance study (N= 593), and the dose-escalation subpopulation of the open-label, long-term extension OCTA
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