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Genitourinary syndrome of menopause (GSM) is a widespread condition with a great impact on quality of life and self-image. We aimed to systematically review the current literature on CO2-Laser therapy efficacy for the treatment of GSM. MEDLINE and Embase databases were systematically queried in December 2020 Studies included women with a diagnosis of Vulvo-Vaginal Atrophy (VVA) or GSM without an history of gynaecological and/or breast cancer, pelvic organ prolapse staged higher than 2, pelvic radiotherapy or Sjogren's Syndrome. The quali