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This research was to develop a reliable and simple high-performance liquid chromatography-tandem size spectrometry (HPLC-MS/MS) to identify paeoniflorin, geniposide, saikosaponin b2, liquiritin, paeonol and atractylenolide Ⅲ in beagle plasma and to learn pharmacokinetic of paeoniflorin and geniposide after single-dose administration of Danzhi Xiaoyao Pill (DZXY). Chromatographic separation ended up being carried out utilizing an Agilent C18 column, and numerous effect monitoring (MRM) mode
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