https://www.selleckchem.com/pr....oducts/Ispinesib-mes
ainst neuropathic pain. Chronic EGF or PDGF administration induces mechanical sensitization, a prominent component of neuropathic pain, and renders animals 'pre-tolerant' to subsequent analgesic doses of morphine. Taken together, these results suggest a direct mechanistic link between opioid tolerance and neuropathic pain. EGFR antagonism could eventually play an important role in the treatment of opioid tolerance and severe neuropathic pain that requires ever increasing doses of opioids. Copyright © 2020 Puig et a
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