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safety concerns of patch use was also highlighted. These elements are included in the trial designs proposed in this study. The systematic review is registered as PROSPERO CRD42017057908. This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in ; Vol. 25, No. 13. See the NIHR Journals Library website for further project information. This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme
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