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coli in CRSwNP subjects and was significantly higher in noneosinophilic CRSwNP subjects than in eosinophilic CRSwNP subjects. Moreover, the LPS levels were positively correlated with GR-β but not GR-α expression in CRSwNP. Immunofluorescence assays showed that LPS was mainly detected in CD68 macrophages and MPO neutrophils, in addition to histiocytes, in CRSwNP. Persistent LPS in CRSwNP can lead to unresolved mucosal inflammation, eventually leading to tissue remodeling and the development of CRSwNP. Our findings suggest t

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