https://www.selleckchem.com/pr....oducts/litronesib.ht
U-87 MG cells were more sensitive to the effect of the inhibition than GAMG cells. The decrease in the number of glioma cells after silencing of the siRNA gene was due to apoptotic and necrotic mechanisms. In human primary fibroblast cultured cells, silencing by siRNA did not produce any change in cell viability. Our results show for the first time that the expression of the (NK-1R) is essential for the viability of GAMG and U-87 MG glioma cells. On the contrary, the is not essential for the viability of normal cells, confirming that
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