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7% (58/112), 91.0% (102/112), and 100% (112/112), respectively. The VRR evaluated by ultrasound and CEUS gradually increased. One recurrent case (0.8%) was found at 7 months after RFA. No complications, lymph node metastasis confirmed by ultrasound, and abnormal thyroid function were observed. This retrospective study shows that RFA is beneficial for the treatment of PTMC in the isthmus. This retrospective study shows that RFA is beneficial for the treatment of PTMC in the isthmus. In this review, we summarize ethnic/race- and age-r