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In vitro HK2 cell experiments also demonstrated the proapoptotic effect of bortezomib. The mRNA phrase of several proapoptotic factors enhanced in kidneys of bortezomib-treated mice. In brief, bortezomib, as a proteasome inhibitor, reveals a specific cytotoxicity to renal tubular epithelial mobile during ischemia/reperfusion injury (IRI) through increased apoptosis. ONX-0914, as an immunoproteasome inhibitor, revealed equal potency on anti-inflammation and oxidative stress relieving comp

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