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Forty-two compounds of a few series had been acquired. The quaternary berberine-12-N,N-di-n-alkylamine chlorides revealed the targeted tasks with the IC50 values on most energetic compounds becoming lots of times those regarding the positive control. An important structure-activity commitment (SAR) ended up being observed. The activities of quaternary berberine-12-N,N-di-n-alkylamine chlorides tend to be significantly stronger than those of this decreased counterparts. In the number o
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