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BACKGROUND Non-anatomic resection (NAR) has emerged as a safe and effective technique for resection of colorectal liver metastases (CRLM). More recently, RAS mutation has been identified as an important indicator of aggressive disease, which may require anatomic resection (AR). In this retrospective study, we compared the long-term outcomes of AR versus NAR in CRLM patients with and without RAS mutations. METHODS Patients with known RAS mutation status who underwent AR or NAR for CRLM between 2006 and 2016 were included. Differences in b