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As the potential risks of BPA exposure in humans are still noteworthy, studies of BPA in CVDs should be strengthened, especially with respect to the mechanisms, prevention and treatment. Moreover, the potential CV risk of BPS reported by in vivo studies calls for immediate epidemiological investigations and animal studies to reveal the relationships of BPS and other BPA alternatives with human CVDs. In this study, we investigated aqueous-phase triplet excited states (3C⁎)-induced photo-degradation of 4-ethylguaiacol (EG) under both simu