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The mean bead volume and topotecan dose delivered were 0.086mL (0.076-0.105mL) and 1.99mg/kg (1.51-2.55mg/kg), respectively. Aspartate aminotransferase and alanine aminotransferase were elevated post-embolization but resolved within 2 weeks. One rabbit died two days after TACE with pyloric duodenal perforation observed at necropsy, potentially due to non-target embolization. In vitro elution of topotecan from ROMTOP was complete in 10h compared to 3h for irinotecan-loaded microspheres. Selective embolization with ROMTOP was tolerated a
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