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To investigated the association between single nucleotide polymorphisms (SNPs) in ( ) gene and susceptibility of rheumatoid arthritis (RA). We systemically extracted the genetic data of from previous genome-wide association studies (GWASs) of RA. Subsequently, we performed a replication study in an independent Chinese cohort for selected variant. A meta-analysis combined the previous GWASs with the replication study was also conducted. The epigenetic annotation and cytokine assay were used for exploring potential variant fu