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Vasodilation, inhibition of epithelial sodium channel, and inhibition of inflammation would be the major EET actions which are beneficial to the heart, opposition arteries, and kidneys. Genetic and pharmacological means to elevate EETs demonstrated antihypertensive, anti-inflammatory, and organ protective activities. Therapeutic methods to increase EETs had been then developed for aerobic diseases. sEH (soluble epoxide hydrolase) inhibitors had been created and progressed to clinical tests for