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In the present study the evaluation of Direct Red 89 (DR89) dye removal from synthetic wastewater by a lab-scale hydrodynamic cavitation (HC) process has been investigated under different operational conditions; the influence of co-existing cations and anions was applied using synthetic wastewater to assess whether the DR89 removal was enhanced. To study the effect of operational parameters, an empirical approach was adopted for the modeling of the HC process. The results showed that the DR89 degradation rate was strongly influenced by solution pH, reaction