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F-κB signaling pathway. The purpose of this study was to compare outcomes between open versus laparoscopic gastrostomies in children aged ≤1y. The American College of Surgeons' National Surgical Quality Improvement Program Pediatric database was reviewed between 2012 and 2017. Chi-square analysis was performed on children aged ≤1y to compare complication rates between open and laparoscopic procedures. A total of 7940 patients were aged ≤1y. Of which, 20% underwent open gastrostomy (OGT), and 80% received laparoscopic gastrostomy (LGT).