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There is scarce evidence revealing an association between job stress and cardiometabolic lifestyle modification behaviors among workers. A cross-sectional, correlation study was conducted among workers in high-risk and low-risk workplaces by work characteristics. Workers in high-risk workplaces had significantly higher job stress levels than low-risk workplaces. Higher job stress was significantly associated with lower cardiometabolic lifestyle modification behaviors (β = -0.14, P = .001). This significant association was evident only fo