https://www.selleckchem.com/pr....oducts/pin1-inhibito
Mandibular advancement devices, more simply known as Oral Appliances (OAs), represent one of the current treatments for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS). The primary objective of the study was to measure their efficacy in the severe OSAHS population. The secondary objectives were to determine predictive factors for the OA efficacy and to determine the tolerance and frequency of treatment discontinuation. OA efficacy outcomes based on Apnea-Hypopnea Index (AHI) reduction, complications, and discontinuation r