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Additionally, we unearthed that ccf-mtDNA levels tend to be connected with comorbidities such as for instance despair and insomnia, nonetheless this is just significant if measured into the lack of therapy. We conclude that in PD, comparable to reports in HIV and sepsis, comorbidities and therapy can both influence ccf-mtDNA homeostasis, increasing the possibility that ccf-mtDNA can be of good use as a biomarker for treatment reacti
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