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decreasing M-current in male mice. These electrophysiological alterations and maladaptive behaviors were mediated by BNST PKA-dependent CRHR1 signaling. Our results thus highlight the importance of BNST CRH dysfunction in chronic stress-induced disorders. Copyright © 2020 the authors.OBJECTIVE To perform a systematic review and meta-analysis of maternal/fetal outcomes in pregnant women with moderate/severe native valvular heart disease (VHD) from medium/higher Human Development Index (HDI) countries. METHODS OvidSP platform databases we
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