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2 years of median follow-up. Taken together, these findings show that de novo lipogenesis contributes to the aggressive phenotype induced by Pten loss in murine prostate and targeting Fasn may reduce the invasive potential of prostate cancer driven by Pten loss. © 2020 The Authors. The Journal of Pathology published by John Wiley Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.Osteosarcoma is the most primary type of bone tumor occurring in the pediatric and adolescent age groups. In order to obtain