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We finally identified 10 hub genes, six of which (OIP5, ASPM, NUSAP1, UBE2C, CCNA2, and KIF20A) are reported as novel HCC hub genes. Data mining the Oncomine database validated that the hub genes have a significant high level of expression in HCC samples compared normal samples (t-test, p less then 0.05). Survival analysis indicated that overexpression of the hub genes is associated with a significant reduction (p less then 0.05) in survival time in HCC patients. CONCLUSIONS We identified six novel HCC hub genes that might be therapeut
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