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To analyse the clinical characteristics of extra-thyroid Tc-pertechnetate uptake in order to explore the effect of the phenomenon on radioactive iodine (RAI) therapy for differentiated thyroid carcinoma (DTC) and its clinical significance. This study retrospectively selected patients with DTC and extra-thyroid Tc-pertechnetate uptake. The clinical features, location, location count and extra-thyroid Tc-pertechnetate uptake distribution were analysed, combined with the uptake rate, stimulated thyroglobulin (sTg) level, post-therapy whole-bo